For the good of the patient: Silica from Evonik in the pharmaceutical industry

Many challenges – one solution: Fumed and precipitated silica from Evonik are some of the most important and highly used pharmaceutical excipients. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product development.

Purity and reliability of raw materials are just two of the many challenges you face as a manufacturer of pharmaceutical products. If high-speed tablet and capsule production equipment, for example, is to run smoothly, the starting materials need to display optimum flow behavior. This is where our silica products come in: As flow aid, they ensure uniform active ingredient content in every tablet or capsule and increase production throughput.

And silica from Evonik can do much more: They can be used to reduce tablet weight without impacting stability. In pharmaceutical creams or viscous gels, they are used as thickening agents. Guaranteeing equal distribution of the active ingredient, these thickening and stabilizing properties are also beneficial when manufacturing active ingredient patches.

Evonik offers a broad portfolio of silica products for the pharmaceutical industry based on more than five decades of experience. Together, we will find the ideal system solutions to make your products even more successful. You can find more information on our portfolio in our Produktfinder.

Benefits of silica from Evonik for the pharmaceutical industry

  • Stabilization of solid dispersions
  • Versatile carrier for liquid or poorly soluble active pharmaceutical ingredients (API)
  • Versatile auxiliary material for orally disintegrating tablets (ODT)
  • Adjustment of rheology in semi-solid medications
  • Improved dissolution of individual active ingredients

Video - Tableting with Moisture-Activated Dry Granulation

Silica from Evonik Regulatory Information

All AEROSIL® Pharma grades are manufactured according to IPEC GMP guidelines for bulk pharmaceutical excipients. Every lot is tested and certified according to compendial methods.

Compendial Compliance of Silica Products

Product
USP/NF
Ph. EUR.
JP
IP
AEROSIL® 200 Pharma
Colloidal silicon dioxide
Silica, colloidal anhydrous
Light anhydrous silicic acid
Silicon dioxide
AEROSIL® 300 Pharma
Colloidal silicon dioxide
Silica, colloidal anhydrous
Light anhydrous silicic acid
AEROPERL® 300 Pharma
Colloidal silicon dioxide
Silica, colloidal anhydrous
*
AEROSIL® R 972 Pharma
Hydrophobic colloidal silica
Silica, hydrophobic colloidal
No monograph
SIPERNAT® 160 PQ
Silicon dioxide
Silica colloidal hydrated
RXCIPIENTS® FM 1000
Calcium silicate
No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists
ZEOPHARM® 600
Calcium silicate
No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists
ZEOPHARM® 250 
Calcium silicate
No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists

* Granulated AEROPERL® 300 Pharma does not fulfill the JP "Volume Test" due to its high bulk density

Recommended Downloads for the Health care Industry

YOU CAN FIND MORE INFORMATION ON OUR PORTFOLIO IN OUR PRODUCTFINDER

FIELDS OF APPLICATION FOR SILICA IN THE Health Care INDUSTRY

Solid Dosage Forms - Sachets

Semi-Solid Dosage Forms - Ointment

Semi-Solid Dosage Forms - Transdermal

Solid Dosage Forms - Capsules

Semi-Solid Dosage Forms - Salves

Semi-Solid Dosage Forms - Suppositories

Solid Dosage Forms - Tablets

Semi-Solid Dosage Forms - Creames